Nutraceutical role of citrates in tissue pH balance: analysis and clinical interpretation of results obtained from urinary pH

Abstract

Unbalanced diets with a high protein load, illness, abuse of drugs and ageing are some of the many elements predisposing to alter tissue pH balance. This, poorly compensated for by buffer systems acting to maintain the acid-base balance, can be a harbinger of: 1) calcium phosphate removal from the bones with osteopenia and, later, osteoporosis; 2) symptomatic aggravation of various pre-existing conditions typically characterized by the presence of pain (arthritis, headache, myalgia and so on); 3) the genesis of new diseases. The scientific literature clearly reports that the administration of citrates, or carbonates, support physiological pH tissue balance and alkalizes urinary pH. In addition, this effect, could reduce the risk of osteopenia and the perception of pain. Non-allopathic medicine describes a situation that is even more severe, secondary to that described above. Wit the progression of impaired balance, the body, probably in an attempt to limit the damage to skeleton structures, could bring about the storage of excess acid in the extracellular matrix by preventing its further elimination in urine, which would then be paradoxically alkaline. The aim of our study was to demonstrate that, even in this case, the administration of citrates can normalize urinary pH, making it acidic. This urinary normalization would be the result of the release of stored acid from connective tissue. This release would also lead to balance tissue pH and this would be monitored through observing the typical symptoms of patients with osteoarthritis, myalgia, headache and migraine, the incidence of which should be significantly reduced.